Deoxyribonucleic acid damage and its detection
نویسندگان
چکیده
منابع مشابه
Methods to Detect Deoxyribonucleic Acid Damage
Deoxyribonucleic acid (DNA) is very stable or conservative in living organism and its primary structure is hardly changed. Several factors that form the living organism or the environment could cause an abnormal change in the DNA structure. As most of the DNA damage could be restored by the repair system present within the organism, the unrepaired DNA damage is very less. Mutation in the gene c...
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Exposure of Escherichia coli to the antibiotic mitomycin C (MTC) at a concentration of 0.5 mug/ml caused cross-linkage between complementary strands of deoxyribonucleic acid (DNA). Derivatives of mitomycin, 7-methoxymitosene (7-MMT) and decarbamoyl mitomycin C (DCMTC), at a level as high as 20 mug/ml formed no cross-links between DNA strands. Ultraviolet light-sensitive mutants of E. coli K-12 ...
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Several classes of cytotoxic agents are known to affect glycolysis in cells by lowering the cellular concentration of NAD. Early investigations showed that both alkylating agents (Roitt, 1956) and ionizing radiation (Maass et al., 1958) were capable of producing this effect, and subsequent research has largely been confined to these agents. Most of the NAD turnover is confined to the cell nucle...
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ژورنال
عنوان ژورنال: Demiroglu Science University Florence Nightingale Transplantation Journal
سال: 2020
ISSN: 2687-3494
DOI: 10.5606/dsufnjt.2019.008